Invitrogen™ BCOR Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA584285

Product Code. 16381235

Description

Immunogen sequence: NINGASYLRL PWVNPYMEGA TPAIYPFLDS PNKYSLNMYK ALLPQQSYSL AQPLYSPVCT NGERFLYLPP PHYVGPHIPS SLASPMRLST PSASPAIPPL VHCADKSLPW KMGVSPGNPV DSHAYPHIQN SKQPRV Highest antigen sequence indentity to the following orthologs: Mouse - 95%, Rat - 95%.

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).

Specifications

• Antigen: BCOR
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Bcor
• Gene Alias: 5830466J11Rik; 8430401K06Rik; ANOP2; BCL6 corepressor; BCL-6 corepressor; BCL6 co-repressor; BCL6 interacting corepressor; BCL-6 interacting corepressor; Bcor; BcorR; D930024N20Rik; Kiaa1575; MAA2; MCOPS2; mKIAA1575; RGD1562735
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54880
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence
• Concentration: 0.10 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6W2J9
• Gene Symbols: Bcor
• Immunogen: Recombinant protein corresponding to Human BCOR. Recombinant protein control fragment (Product #RP-106693).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG