Invitrogen™ BCLAF1 Polyclonal Antibody

Code produit.	Quantity	unitSize
15793601	100 μL	100µL

Code produit. 15793601 missing translation for 'mfr' Invitrogen™ missing translation for 'supplierNo' PA555686

Description

Rabbit Polyclonal Antibody

Immunogen sequence: QKSPEIHRRI DISPSTLRKH TRLAGEERVF KEENQKGDKK LRCDSADLRH DIDRRRKERS KERGDSKGSR ESSGSRKQEK TPKDYKEYKS YKDDSKHKRE QDHSRSSSSS ASPSSPSSR Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.

BCLAF1 is an intracellular, death promoting transcriptional repressor of survival genes that interacts with several members of the BCL2 family of proteins. It shows homology to the basic leucine zipper (bzip) and MYB DNA binding domains.From recent research it can be concluded that in case of apoptotic cells this protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope. When over expressed this protein induces apoptosis and can be suppressed by co-expression of BCL2 proteins. Also known as BTF, it triggers a proapoptotic signal, potentially helpful to overcome the resistance to STI571.BCLAF1 is found to express mostly in skeletal muscles.

Spécification

• Antigen: BCLAF1
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: BCLAF1
• Gene Accession No.: Q9NYF8
• Gene Alias: 2610102K23Rik; 2700025J07Rik; 2810454G14Rik; 5730534O06Rik; Aa2-041; AI450190; AW556225; BCL2 associated transcription factor 1; bcl-2-associated transcription factor 1; BCL2-associated transcription factor 1; Bcl-2-associated transcription factor 1-like protein; BCLAF1; BCLAF1 and THRAP3 family member 1; bK211L9.1; BP-1; BTF; Btf-s; KIAA0164; mKIAA0164
• Gene Symbols: BCLAF1
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human BCLAF1. Recombinant protein control fragment (Product #RP-89287).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 9774
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG