Invitrogen™ BCL2L15 Monoclonal Antibody (K06343_5E8), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA556326

Product Code. 30204483

Description

Sequence of this protein is as follows: TECIVNTLLM DFLSPTLQVA SRNLCCVDEV DSGEPCSFDV AIIAGRLRML GDQFNGELEA SAKNVIAETI KGQTGAILQD TVESLSKTWC AQDSSLAYER AFLAVSVKLL EYMAHIAPEV VGQVAIPMTG MINGNQAIRE FIQGQGGWEN

Proteins of the Bcl-2 family are critical regulators of apoptosis. Proapoptotic members, like Bax, contain three of the four Bcl-2 homology regions (BH1-3), while BH3-only proteins, like Bim, possess only the short BH3 motif. Database searches revealed Bfk, an unusual novel member of the Bcl-2 family that contains a BH2 and BH3 region but not BH1 or BH4. Bfk is thus most closely related to Bcl-G(L). It lacks a C-terminal membrane anchor and is cytosolic. Enforced expression of Bfk weakly promoted apoptosis and antagonized Bcl-2's prosurvival function. Like Bcl-G(L), Bfk did not bind to any Bcl-2 family members, even though its BH3 motif can mediate association with prosurvival proteins. Low amounts of Bfk were found in stomach, ovary, bone marrow and spleen, but its level in the mammary gland rose markedly during pregnancy, suggesting that Bfk may play a role in mammary development.

Specifications

• Antigen: BCL2L15
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol, 0.5% BSA and 0.09% sodium azide
• Gene Accession No.: Q5TBC7
• Gene Symbols: BCL2L15
• Immunogen: Recombinant human BCL2L15 (immunogen range is 11-160).
• Quantity: 200 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: K06343_5E8
• Conjugate: Unconjugated
• Gene: BCL2L15
• Gene Alias: BCL2 like 15; BCL2L15; bcl2-L-15; BCL2-like 15; bcl-2-like protein 15; BCLl2-like 15; Bfk; C1orf178; Gm566; pro-apoptotic Bcl-2 protein; RGD1562344
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 440603
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid