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Bcl-6 Antibody (BCL6/1982) - Azide and BSA Free, Novus Biologicals™

Product Code. 18348470 Shop All Bio Techne Products
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Quantity:
100 μg
Unit Size:
100µg
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18348470 100 μg 100µg
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Product Code. 18348470 Supplier Novus Biologicals Supplier No. NBP275749

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Description

Mouse Monoclonal Antibody

Bcl-6 Monoclonal specifically detects Bcl-6 in Human samples. It is validated for ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Protein Array.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Bcl-6
Applications ELISA, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone BCL6/1982
Concentration 0.2 mg/ml
Conjugate Unconjugated
Dilution ELISA, Immunohistochemistry-Paraffin 1-2 ug/ml
Formulation 10 mM PBS with No Preservative
Gene Accession No. P41182
Gene Alias B-cell CLL/lymphoma 6, B-cell lymphoma 6 protein transcript, BCL-5, BCL5B-cell lymphoma 5 protein, BCL-6, BCL6A, cys-his2 zinc finger transcription factor, LAZ3ZBTB27B-cell lymphoma 6 protein, lymphoma-associated zinc finger gene on chromosome 3, Protein LAZ-3, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51ZNF51, zinc finger transcription factor BCL6S
Gene Symbols BCL6
Host Species Mouse
Immunogen Recombinant human bcl-6 protein fragment (around aa256-389) (exact sequence is proprietary) (Uniprot: P41182)
Molecular Weight of Antigen 95 kDa
Purification Method Protein A or G purified
Quantity 100 μg
Research Discipline Cancer, Cell Cycle and Replication, Tumor Suppressors
Primary or Secondary Primary
Gene ID (Entrez) 604.0
Test Specificity Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ('LH') cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
Target Species Human
Content And Storage Store at 4°C.
Form Purified
Isotype IgG1 κ
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