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Tocris Bioscience™ BCI
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Product Code. 18775785
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Quantity:
50 mg
Unit Size:
50mg
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Product Code. 18775785

Brand: Tocris Bioscience™ 7481/50

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This item is not returnable. View return policy

Description

DUSP6 and DUSP1 inhibitor

BCI is an allosteric inhibitor of dual specificity phosphatase DUSP6 and DUSP1 (EC50 values are 8.0 μM and 13.3 μM respectively). Increases P2X7 receptor expression in neuroblastoma cells, reduces cell viability of EGFR or KRAS mutant lung cancer cells, and induces apoptosis in p53-null non-small cell lung cancer cells. In an animal model of myocardial infarction, BCI improves heart function, reduces fibrosis, and reduces inflammation by inhibiting macrophage formation. Activates FGF signaling in zebrafish embryo development to increase myocardial progenitor population and heart size.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 3-(Cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-1 H-inden-1-one
CAS 15982-84-0
Quantity 50 mg
Target MKP-1/DUSP1
Molecular Formula C22H23NO
Purity 0.98
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