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  5. Tocris™ BAY 87-2243

Tocris™ BAY 87-2243

Product Code. 18788036
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5 mg
25 mg
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25mg
5mg
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18788036 25 mg 25mg
18778836 5 mg 5mg
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Product Code. 18788036 Supplier Tocris™ Supplier No. 6980/25

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Description

Mitochondrial complex I inhibitor

BAY 87-2243 is a mitochondrial complex I inhibitor. Exhibits no effect on mitochondrial complex III. Induces mitochondrial permeability transition pore (mPTP) opening, stimulates autophagosome formation and mitophagy, and increases ROS levels. Activates necroptotic and ferroptotic cell death. Also inhibits hypoxia-induced gene activation. Induces cell death in melanoma cell lines in vitro and exhibits antitumor activity in a mouse NSCLC xenograft model in vivo.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 1-Cyclopropyl-4-[4-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-pyrazol-1-yl]methyl]-2-pyridinyl]piperazine
CAS 1227158-85-1
Quantity 25 mg
Molecular Formula C26H26F3N7O2
Purity 98%
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