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Invitrogen™ BAG4 Polyclonal Antibody

Product Code. 12828142
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
12828142 100 μg 100µg
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Product Code. 12828142 Supplier Invitrogen™ Supplier No. PA519925

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Description

Rabbit Polyclonal Antibody

In Western blot applications, this antibody detects a band at ~60kDa. A suggested positive control is Hela cell lysate. PA5-19925 can be used with blocking peptide PEP-0050.

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BAG4
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene BAG4
Gene Accession No. O95429, Q8CI61
Gene Alias 2410112I15Rik; BAG cochaperone 4; BAG family molecular chaperone regulator 4; BAG4; BAG-4; BAG-family molecular chaperone regulator-4; BCL2 associated athanogene 4; Bcl-2-associated athanogene 4; BCL2-associated athanogene 4; silencer of death domains; SODD
Gene Symbols BAG4
Host Species Rabbit
Immunogen A peptide corresponding to amino acids near the amino terminus of human SODD.
Purification Method Ion-exchange chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 361167, 67384, 9530
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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