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Invitrogen™ BAG4 Polyclonal Antibody
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Product Code. 17198763
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Quantity:
100 μL
Unit Size:
100µL
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17198763 100 μL 100µL
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Product Code. 17198763 Supplier Invitrogen™ Supplier No. PA5110845

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VHQYESSGTV NNDDSDLLDS QVQYSAEPQL YGNATSDHPN NQDQSSSLPE ECVPSDESTP PSIKKIIHVL EKVQYLEQ Highest antigen sequence indentity to the following orthologs: Mouse - 82%, Rat - 81%.

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BAG4
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene BAG4
Gene Accession No. O95429
Gene Alias 2410112I15Rik; BAG cochaperone 4; BAG family molecular chaperone regulator 4; BAG4; BAG-4; BAG-family molecular chaperone regulator-4; BCL2 associated athanogene 4; Bcl-2-associated athanogene 4; BCL2-associated athanogene 4; silencer of death domains; SODD
Gene Symbols BAG4
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human BAG4. Recombinant protein control fragment (Product #RP-92059).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9530
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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