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Invitrogen™ BACE2 Polyclonal Antibody

Product Code. 12858162
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Quantity:
100 μg
Unit Size:
100µg
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12858162 100 μg 100µg
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Product Code. 12858162 Supplier Invitrogen™ Supplier No. PA519951

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Description

Rabbit Polyclonal Antibody

A suggested positive control is human heart tissue lysate. PA5-19951 can be used with blocking peptide PEP-0076.

BACE2 or Beta Secretase 2 is responsible for the proteolytic processing of the amyloid precursor protein (APP). BACE2 cleaves APP between residues 690 and 691. This cleavage leads to the generation and extracellular release of beta-cleaved soluble APP. BACE2 is also know to cleave APP between residues 671 and 672. Accumulation of APP is a signature of Alzheimer disease and frequent complication of adult Down syndrome patients.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BACE2
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene BACE2
Gene Accession No. Q6IE75, Q9Y5Z0
Gene Alias 1110059C24Rik; 56 kDa aspartic-like protease; AEPLC; AI850424; ALP56; ARP1; asp 1; ASP1; ASP21; Aspartic-like protease 56 kDa; Aspartyl protease 1; Bace2; BAE2; be; beta secretase 2; Beta-secretase 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; beta-site APP-cleaving enzyme 2; CDA13; CEAP1; Down region aspartic protease; Down syndrome region aspartic protease; DRAP; memapsin 1; memapsin-1; Membrane-associated aspartic protease 1; theta-secretase; transmembrane aspartic proteinase Asp1; UNQ418/PRO852
Gene Symbols BACE2
Host Species Rabbit
Immunogen A peptide corresponding to amino acids near the carboxy terminus of human BACE2.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25825, 288227
Target Species Human, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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