BACE1 Rabbit anti-Human, Mouse, Zebrafish, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 12807-1-AP-20UL

Product Code. 16810724

Description

Accumulation of the amyloid-b (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis Alzheimer′s disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor(APP) at b- and g-sites by two proteases. APP is first cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-b peptide, which is deposited in the brains of all sufferers of Alzheimer′s disease. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). bACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.

Specifications

• Antigen: BACE1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BACE1
• Gene Alias: Asp 2, ASP2, Aspartyl protease 2, BACE, BACE1, Beta secretase 1, HSPC104, KIAA1149, Memapsin 2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23621, 23821, 403005
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunoprecipitation, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.19 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P56817, P56818
• Gene Symbols: bace1
• Immunogen: BACE1 Fusion Protein Ag3559
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Zebrafish, Human
• Product Type: Antibody
• Isotype: IgG