Invitrogen™ B-Raf (V600E) Recombinant Rabbit Monoclonal Antibody (4R4T5)

Rabbit Recombinant Monoclonal Antibody

Product Code	Brand	Quantity
30284381	Invitrogen™ MA557887	20 μL
30284389	Invitrogen™ MA557888	100 μL

Description

Immunogen sequence: KTRHVNILLF MGYSTKPQLA IVTQWCEGSS LYHHLHIIET KFEMIKLIDI ARQTAQGMDY LHAKSIIHRD LKSNNIFLHE DLTVKIGDFG LATVKSRWSG.

This gene, B-RAF/BRAF, encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome.

Specifications

• Antigen: B-Raf (V600E)
• Concentration: 1.79 mg/mL
• Applications: ELISA, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: P15056
• Gene Symbols: BRAF
• Primary or Secondary: Primary
• Purification Method: Protein A

• Clone: 4R4T5
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human
• Gene: BRAF
• Gene ID (Entrez): 673
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 507-606 of B-Raf (NP_004324.2).
• Product Type: Antibody