Azithromycin dihydrate, Thermo Scientific™

Azithromycin dihydrate, CAS # 117772-70-0, is an azalide derived from erythromycin that shows antibacterial activity.

Brand:  Thermo Scientific Alfa Aesar J66740.06

Product Code. 15498209

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

General Description

• Azithromycin dihydrate is the dihydrate form of azithromycin, an azalide derived from erythromycin, that shows antibacterial activity

• Azithromycin dihydrate reversibly binds to the 23S rRNA of the 50S ribosomal subunit of the bacterial ribosome of susceptible microorganisms, inhibiting the translocation step of protein synthesis by preventing the assembly of the 50S ribosomal subunit. This inhibits bacterial protein synthesis and cell growth, causing cell death

Application

• Azithromycin dihydrate shows anti-immunomodulatory and anti-inflammatory activities

• It shows antimalarial activity against Plasmodium falciparum and P. vivax, which are multidrug-resistant species

• In the laboratory, azithromycin dihydrate has been used in blocking buffer for indirect immunofluorescence

• It has been used in U87 cells for cell viability assay and flow cytometry analysis to study the Zika virus infection in glial cells

• Azithromycin dihydrate has been used in experiments to compare its antibacterial activity with PYRRO-C3D against Streptococcus pneumoniae biofilms

Specifications

• CAS: 117772-70-0
• Quantity: 5g
• Sensitivity: Air sensitive
• MDL Number: MFCD01862248
• Synonym: N-Methyl-11-aza-10-deoxo-10-dihydroerythromycin A; CP-62993
• InChI Key: SRMPHJKQVUDLQE-GTCGPNQGSA-N
• IUPAC Name: (2R,3S,4S,5R,8R,10R,11R,12S,13R,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-o
• PubChem CID: 131845180
• Percent Purity: 98%

• Color: White
• Flash Point: >110°C (230°F)
• Molecular Formula: C38H76N2O14
• Boiling Point: 717°C
• Solubility Information: Soluble in DMSO at 20mg/mL; Also soluble in chloroform or ethylene chloride
• SMILES: CCC1C(C(C(N(CC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O.O.O
• Molecular Weight (g/mol): 785.026
• Formula Weight: 785.01
• Chemical Name or Material: Azithromycin dihydrate

Safety and Handling

Product Identifier

• Azithromycin dihydrate

Signal Word

• Danger

Hazard Category

• Respiratory sensitiser Category 1
• Skin sensitiser Category 1

Hazard Statement

• H317-May cause an allergic skin reaction.
• H334-May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P284-¢In case of inadequate ventilation! wear respiratory protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P333+P313-If skin irritation or rash occurs: Get medical advice/attention.
• P342+P311-If experiencing respiratory symptoms: Call a POISON CENTER/doctor/ .
• P362+P364-Take off contaminated clothing and wash it before reuse.

Supplemental information

• MIXTURE LIST-Contain: Azithromycin hydrate