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  8. AZD3839 free base, MedChemExpress

AZD3839 free base, MedChemExpress

Product Code. 16481847
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Product Code. 16481847 Supplier Medchem Express Supplier No. HY13438

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Description

MedChemExpress AZD3839 free base is a potent and selective orally active, brain-permeable BACE1 inhibitor (Ki=26 nM).

AZD3839 free base shows 14 and >1000-fold selectivity against BACE2 and cathepsin D, respectively. AZD3839 free base exhibits dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid Aβ levels in mouse, guinea pig, and non-human primate. AZD3839 free base can be used for the research of Alzheimer's disease.

Specifications

Chemical Name or Material AZD3839 free base
CAS 1227163-84-9
Color White
Purity Grade Notes Research
Molecular Formula C24H16F3N5
Quantity 50 mg
Solubility Information DMSO : 125 mg/mL (289.75 mM; Need ultrasonic)
SMILES FC1=C2C([C@](C3=CC=CC(C4=CN=CN=C4)=C3)(C5=CC(C(F)F)=NC=C5)N=C2N)=CC=C1
Molecular Weight (g/mol) 431.41
Formula Weight 431.41
Percent Purity 99.89%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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