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  5. Tocris Bioscience™ AZD 2461

Tocris Bioscience™ AZD 2461

Product Code. 30000999
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50 mg
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30000999 50 mg 50mg
30000929 10 mg 10mg
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Product Code. 30000999 Supplier Tocris Bioscience™ Supplier No. 6060/50

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280.50 GBP valid until 2026-03-31
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Description

Potent PARP inhibitor; orally bioavailable

AZD 2461 is a potent PARP inhibitor (IC50 values are 2, 5 and 200 nM for PARP2, PARP1 and PARP3, respectively). Exhibits anticancer effects in BRCA1 mutant, but not wild-type breast cancer cell lines in vitro. Inhibits growth of olaparib -resistant mammary tumors in a mouse model and is a poor substrate for the P-gp transporter. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 1174043-16-3
Molecular Formula C22H22FN3O3

Specifications

Quantity 50 mg
Solubility Soluble to 100mM in DMSO and to 100mM in ethanol
Formula Weight 395.43
Physical Form Solid
Purity >98%
Molecular Weight (g/mol) 395.434
Chemical Name or Material 4-[[4-Fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone
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