AVPR2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA577763

Product Code. 15964265

Description

Product is shipped at room temperature as a lyophilized powder and should be stored at -20C upon receipt. Reconstitute using 50 uL deionized water.

Avpr2 is a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin 2 and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. Avpr2 has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. Avpr2 can contract smooth muscle during parturition and lactation. Avpr2 is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. The activity of Avpr2 is mediated by G proteins which activate adenylate cyclase.

Specifications

• Antigen: AVPR2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Avpr2
• Gene Alias: Arginine Vasopressin Receptor 2, Antidiuretic Hormone Receptor, Nephrogenic Diabetes Insipidus, V2R
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12000, 25108
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Western Blot
• Concentration: 0.85 mg/mL
• Formulation: PBS with 1% BSA and 0.05% sodium azide; pH 7.4
• Gene Accession No.: O88721, Q00788
• Gene Symbols: Avpr2
• Immunogen: Peptide RHTTHSLGPQDESC, corresponding to amino acid residues 345-358 of rat Vasopressin V2 Receptor
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG