Invitrogen™ AVEN Recombinant Rabbit Monoclonal Antibody (24GB6865)

Rabbit Recombinant Monoclonal Antibody

Product Code	Brand	Quantity
30276363	Invitrogen™ MA556989	100 μL
30276578	Invitrogen™ MA556990	20 μL

Beschreibung

AVEN Recombinant Monoclonal Antibody for Western Blot

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients.

Spezifikation

• Antigen: AVEN
• Content And Storage: -20°C
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human, Mouse, Rat
• Gene: AVEN
• Gene Alias: 1700013A01Rik; 1700056A21Rik; apoptosis and caspase activation inhibitor; apoptosis, caspase activation inhibitor; AVEN; Cell death regulator Aven; mAven-L; mAven-S; PDCD12; programmed cell death 12
• Gene Symbols: AVEN
• Primary or Secondary: Primary
• Purification Method: Affinity chromatography

• Clone: 24GB6865
• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q9D9K3, Q9NQS1
• Gene ID (Entrez): 311299, 57099, 74268
• Immunogen: A synthesized peptide derived from human AVEN (aa 113-126).
• Product Type: Antibody