Invitrogen™ AVEN Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA588858

Product Code. 16586941

Description

Immunogen sequence: VQGTVPLEVP QVKPKRTDDG KGLGMQLKGP LGPGGRGPIF ELKSVAAGCP VLLGKDNPSP GPSRDSQKPT SPLQSAGDHL EEELDLLLNL DAPIKEGDNI LPDQTSQDLK SKEDGEVVQE EEVCAKPSVT EEKNMEPEQP STSKNVTEEE LEDWLDSMIS; Positive Samples: 22RV1, HT-29, LO2, HeLa; Cellular Location: Endomembrane system, Peripheral membrane protein.

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients.

Specifications

• Antigen: AVEN
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AVEN
• Gene Alias: 1700013A01Rik; 1700056A21Rik; apoptosis and caspase activation inhibitor; apoptosis, caspase activation inhibitor; AVEN; Cell death regulator Aven; mAven-L; mAven-S; PDCD12; programmed cell death 12
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 311299, 57099
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.91 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q9NQS1
• Gene Symbols: AVEN
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 203-362 of human AVEN (NP_0651041).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG