Invitrogen™ Avdoralimab Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

Marca:  Invitrogen™ MA559098

Código de producto. 30283473

Descripción

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.

Avdoralimab is a biosimilar that targets C5AR1. CD88, also known as C5aR1, is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known. C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. CD88 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, CD88 stimulates chemotaxis, granule enzyme release and superoxide anion production. CD88 is also a component of the classical pathway of the complement cascade; it may be involved with tissue injury associated with ischemia or sepsis and it may be a component of the membrane attack complex. Diseases associated with CD88 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.

Especificaciones

• Antigen: Avdoralimab
• Classification: Recombinant Monoclonal
• Conjugate: Unconjugated
• Gene Alias: IPH-5401; NN-8210; NNC-0215-0384
• Purification Method: Protein A
• Regulatory Status: RUO
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Flow Cytometry, Functional Assay
• Concentration: 1 mg/mL
• Formulation: 25mM histidine with 8% sucrose, 0.01% Tween 80 and no preservative; pH 6.2
• Host Species: Human
• Quantity: 1 mg
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized