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Avapritinib, MedChemExpress

Product Code. 16494636
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Product Code. 16494636

Brand: Medchem Express HY101561

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Description

MedChemExpress Avapritinib (BLU-285) is a highly potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor with IC50s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V, respectively. Avapritinib (BLU-285) binds the active conformation of the kinase and shows antitumor activity. Avapritinib (BLU-285) attenuates the transport function of both ABCB1 and ABCG2.

Avapritinib (BLU-285) is a highly potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor with IC50s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V, respectively. Avapritinib (BLU-285) binds the active conformation of the kinase and shows antitumor activity. Avapritinib (BLU-285) attenuates the transport function of both ABCB1 and ABCG2.

Specifications

Chemical Name or Material Avapritinib
CAS 1703793-34-3
Color Off-White
Purity Grade Notes Research
Molecular Formula C26H27FN10
Quantity 100 mg
Synonym BLU-285
Solubility Information DMSO : ≥ 83.33 mg/mL (167.14 mM)
SMILES CN1N=CC(C2=CN3C(C(N4CCN(C5=NC=C([C@@](C)(N)C6=CC=C(F)C=C6)C=N5)CC4)=NC=N3)=C2)=C1
Molecular Weight (g/mol) 498.56
Formula Weight 498.56
Percent Purity 99.46%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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