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  5. Tocris Bioscience™ Avagacestat

Tocris Bioscience™ Avagacestat

Product Code. 18787596
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25 mg
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18787596 5 mg 5mg
18749576 25 mg 25mg
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Product Code. 18787596 Supplier Tocris Bioscience™ Supplier No. 6363/5

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Description

Highly potent γ-secretase inhibitor; orally bioavailable

Avagacestat is a highly potent γ-secretase inhibitor (Aβ40 IC50 = 0.3 nM). Exhibits >137-fold selectivity for amyloid-β precursor protein (APP) processing over Notch. Reduces plasma and brain Aβ40 and Aβ42 levels in vivo. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material (2R)-2-[[(4-Chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide
CAS 1146699-66-2
Synonym BMS-708163
Quantity 5 mg
Molecular Formula C20H17ClF4N4O4S
Formula Weight 520.89
Purity 98%
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