missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Benzenoids
  6. Benzene and substituted derivatives
  7. Fluorobenzenes
  8. Avagacestat, MedChemExpress

Avagacestat, MedChemExpress

Product Code. 16468108
Encompass_Preferred
Change view
Click to view available options
Quantity:
5 mg
10 mg
50 mg
Unit Size:
10mg
50mg
5mg
3 product options available for selection
Product selection table with 3 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity unitSize
16468108 10 mg 10mg
16460568 5 mg 5mg
16444027 50 mg 50mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 3 options available.
3 options
This item is not returnable. View return policy
Product Code. 16468108 Supplier Medchem Express Supplier No. HY50845

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

MedChemExpress Avagacestat (BMS-708163) is a potent inhibitor of γ-secretase, with IC50s of 0.27 nM and 0.30 nM for Aβ42 and Aβ40 inhibition; Avagacestat (BMS-708163) also inhibits NICD (Notch IntraCellular Domain) with IC50 of 0.84 nM and shows weak inhibition of CYP2C19, with IC50 of 20 μM. Avagacestat can be used for Alzheimer disease research.

Avagacestat (BMS-708163) is a potent inhibitor of γ-secretase, with IC50s of 0.27 nM and 0.30 nM for Aβ42 and Aβ40 inhibition

Specifications

Chemical Name or Material Avagacestat
CAS 1146699-66-2
Color White
Purity Grade Notes Research
Molecular Formula C20H17ClF4N4O4S
Quantity 10 mg
Synonym BMS-708163
Solubility Information DMSO : ≥ 100 mg/mL (191.98 mM)
SMILES O=S(N([C@@H](C(N)=O)CCC(F)(F)F)CC1=CC=C(C2=NOC=N2)C=C1F)(C3=CC=C(Cl)C=C3)=O
Molecular Weight (g/mol) 520.89
Formula Weight 520.89
Percent Purity 95.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-programmed cell death
Show More Show Less

Research purposes only

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.