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Invitrogen™ Aurora A Monoclonal Antibody (1F8)

Product Code. 12867822
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
12867822 100 μL 100µL
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Product Code. 12867822 Supplier Invitrogen™ Supplier No. MA515803

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Description

Mouse Monoclonal Antibody

MA5-15803 targets AURKA in indirect ELISA, FACS, IF, and WB applications and shows reactivity with Human, Non-human primate, and Rat samples. The MA5-15803 immunogen is purified recombinant fragment of human AURKA expressed in E. Coli. MA5-15803 detects AURKA which has a predicted molecular weight of approximately 48kDa.

AURKA (Aurora A) is a serine/threonine kinase that regulates mitosis by association in vivo with centrosomes. Overexpression of AURKA is observed in many types of cancer. Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment. Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Aurora A
Applications ELISA, Flow Cytometry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 1F8
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites with 0.03% sodium azide
Gene AURKA
Gene Accession No. O14965, P59241
Gene Alias Aik; Airk; AIRK1; Ark1; ARK-1; AU019385; AURA; AURAK; AURKA; Aurora 2; aurora A; Aurora A Kinase; aurora family kinase 1; Aurora kinase A; aurora/IP; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; AURORA2; Aurora-A; aurora-related kinase 1; AW539821; Ayk1; Breast tumor-amplified kinase; BTAK; EC 2.7.11.1; hARK1; IAK; IAK1; Ipl1- and aurora-related kinase 1; IPL1-related kinase; MGC34538; OTTHUMP00000031341; OTTHUMP00000166072; PPP1R47; protein phosphatase 1, regulatory subunit 47; ratAurA; RP5-1167H4.6; sereine threonine kinase; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine protein kinase 6; serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; serine/threonine-protein kinase 6; aurora kinase A; serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase Ayk1; STK15; STK6; STK7; Unknown (protein for MGC:134472)
Gene Symbols AURKA
Host Species Mouse
Immunogen Purified recombinant fragment of human AURKA expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 261730, 6790
Target Species Human, Rat, Monkey
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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