Invitrogen™ ATXN7L3B Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA566027

Product Code. 15938754

Description

Immunogen sequence: VKCGYFYLEFA ETGSVKDFGI QPVEDKGACR LPLCSLPGEP GNGPDQQLQR SPPEFQ Highest antigen sequence identity to the following orthologs - mouse 89%, rat 93%.

By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of ENY2 and altering ENY2 availability for ATXN7L3 interaction. Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2 resulting in loss of nuclear ENY2-ATXN7L3 association which destabilizes ATXN7L3. Affects protein expression levels of ENY2 and ATXN7L3.

Specifications

• Antigen: ATXN7L3B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ATXN7L3B
• Gene Alias: 4921506J03Rik; 6230409E21Rik; AI315132; ataxin 7 like 3B; ataxin 7-like 3B; Ataxin-7-like protein 3B; ATXN7L3B; ENSMUSG00000074747; lnc-SCA7; putative ataxin-7-like protein 3B; putative ataxin-7-like protein 3-like protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 552889
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96GX2
• Gene Symbols: ATXN7L3B
• Immunogen: Recombinant Human ATXN7L3B. Recombinant protein control fragment (Product #RP-106717).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG