Invitrogen™ ATP2C2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA521127

Product Code. 12829272

Description

A suggested positive control is NIH-3T3 cell lysate. PA5-21127 can be used with blocking peptide PEP-1241.

ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.

Specifications

• Antigen: ATP2C2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ATP2C2
• Gene Alias: 1810010G06Rik; Atp2c2; ATPase 2C2; ATPase secretory pathway Ca2+ transporting 2; ATPase, Ca++ transporting, type 2C, member 2; calcium-transporting ATPase type 2C member 2; Kiaa0703; mKIAA0703; Secretory pathway Ca(2+)-ATPase 2; secretory pathway Ca2+-ATPase; secretory pathway calcium ATPase 2; Spca2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 69047, 9914
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: A7L9Z8, O75185
• Gene Symbols: ATP2C2
• Immunogen: A 19 amino acid peptide near the amino terminus of human ATP2C2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG