ATP1A2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 55179-1-AP-20UL

Product Code. 16816665

Description

This antibody is specific to ATP1A2.

Atp1a2 encodes an Na+/K+ ATPase, which is a membrane protein that is composed of two subunits - alpha and beta. The Na+/K+ ATPase pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions. The Atp1a2 encoded protein belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These ion gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. The ATPase enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta), and the catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. The Atp1a2 gene encodes an alpha 2 subunit. Mutations in the Atp1a2 gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. Diseases associated with ATP1A2 include Alternating Hemiplegia Of Childhood and Migraine, Familial Hemiplegic, 2.

Specifications

• Antigen: ATP1A2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ATP1A2
• Gene Alias: ATP1A2, FHM2, KIAA0778, MHP2, Sodium pump subunit alpha 2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 477, 98660
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunoprecipitation
• Concentration: 0.13 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P50993, Q6PIE5
• Gene Symbols: ATP1A2
• Immunogen: Peptide
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG