ATP11A Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Thermo Scientific PA557323

Product Code. 15745221

Description

Immunogen sequence: SATGEIYLFC KGADSSIFPR VIEGKVDQIR ARVERNAVEG LRTLCVAYKR LIQEEYEGIC KLLQAAKVAL QDREKKLAEA YEQIEKDLTL LG Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.

ATP11A is a widely expressed integral membrane ATPase. ATP11A is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium or other molecules across membranes. While the exact molecule ATP11A transports is unknown, increased expression of ATP11A mRNA has been observed in murine leukemia cells made resistant to anti-cancer drugs such as farnesyltransferase inhibitors (FTIs). Furthermore, overexpression of ATP11A provided protection against the FTI SCH66336 while knockdown of ATP11A via siRNA made cells more sensitive to this drug. Other reports suggest that elevated levels of ATP11A mRNA may also be a predictive marker of metastasis in colorectal cancer patients.

Specifications

• Antigen: ATP11A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ATP11A
• Gene Alias: 4930558F19Rik; ATP11A; ATPase 11A, class VI; ATPase 11A, p type; ATPase class VI type 11A; ATPase IS; ATPase phospholipid transporting 11A; ATPase, class 1, member h; ATPase, class VI, type 11A; Atpc1h; ATPIH; ATPIS; AU040868; Ih; KIAA1021; P4-ATPase flippase complex alpha subunit ATP11A; phospholipid-translocating ATPase; potential phospholipid-transporting ATPase IH; probable phospholipid-transporting ATPase IH; RP11-120K24.1; Ua20
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23250
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P98196
• Gene Symbols: ATP11A
• Immunogen: Recombinant protein corresponding to Human ATP11A
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Research Use Only