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Invitrogen™ ATOH8 Polyclonal Antibody

Product Code. 12858852
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Quantity:
100 μg
Unit Size:
100µg
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12858852 100 μg 100µg
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Product Code. 12858852 Supplier Invitrogen™ Supplier No. PA520710

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Description

Rabbit Polyclonal Antibody

A suggested positive control is A-20 cell lysate. PA5-20710 can be used with blocking peptide PEP-0825.

Basic helix-loop-helix (bHLH) transcription factors play important roles in differentiation processes during embryonic development of vertebrates. ATOH8 (MATH6) is a tissue-restricted member of the atonal superfamily of bHLH transcription factors that exhibits 43-57% identity in the bHLH domain with other mammalian atonal paralogs including the NeuroD and Neurogenin factors. In the mouse, ATOH8 has been implicated in the specification and differentiation of neuronal cell lineages in the brain and may also participate in kidney development. Recent studies show that ATOH8 is a novel component of the pancreatic transcriptional network during embryonic development and suggest a potential role as a modulator of the differentiation program initiated by the pro-endocrine factor Neurog3. It is indispensable for early embryonic development, suggesting a more widespread function for this factor in tissue-specific differentiation processes that are dependent on class II bHLH genes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATOH8
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene ATOH8
Gene Accession No. Q96SQ7, Q99NA2
Gene Alias 4933425C05Rik; Ath6; Atoh8; atonal bHLH transcription factor 8; atonal homolog 6; atonal homolog 8; atonal homolog 8 (Drosophila); atonal homolog bHLH transcription factor 8; basic helix loop helix transcription factor 6; basic helix-loop-helix transcription factor 6; bHLHa21; Class A basic helix-loop-helix protein 21; hATH6; Helix-loop-helix protein hATH-6; helix-loop-helix protein mATH-6; mATH6; Okadin; Protein atonal homolog 8; RGD1561512
Gene Symbols ATOH8
Host Species Rabbit
Immunogen A 15 amino acid peptide near the carboxy terminus of human ATOH8.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 500200, 71093, 84913
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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