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Invitrogen™ ATGL Monoclonal Antibody (494702)
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Product Code. 15553892
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Quantity:
100 μg
Unit Size:
100µg
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15553892 100 μg 100µg
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Product Code. 15553892 Supplier Invitrogen™ Supplier No. MA524202

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Description

Mouse Monoclonal Antibody

In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse PEDF R is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

Lipolytic enzymes are required for mobilization of fatty acids from triglyceride stores in adipose tissue. Energy homeostasis is affected by dysfunctional lipolysis and may contribute to the pathogenesis of obesity and insulin resistance. Until recently, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. It is now thought that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATGL
Applications Flow Cytometry, Western Blot
Classification Monoclonal
Clone 494702
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene PNPLA2
Gene Accession No. Q96AD5
Gene Alias 0610039C21Rik; 1110001C14Rik; adipose triglyceride lipase; ATGL; ATGL DESNUTRIN; calcium-independent phospholipase A2; Desnutrin; DKFZp667M109; FP17548; IPLA2 zeta; iPLA2zeta; IPLA2-zeta; mutant patatin-like phospholipase domain containing 2; patatin like phospholipase domain containing 2; patatin-like phospholipase domain containing 2; patatin-like phospholipase domain containing protein 2; patatin-like phospholipase domain-containing protein 2; PEDF R; PEDF-R; pigment epithelium-derived factor; plpl; plpl2; Pnpla2; RGD1309044; transport-secretion protein; Transport-secretion protein 2; transport-secretion protein 2.2; triglyceride hydrolase; TTS 2.2; TTS2; TTS2.2; TTS-2.2
Gene Symbols PNPLA2
Host Species Mouse
Immunogen E. coli-derived recombinant human PEDF R/PNPLA2 Val162-Thr332.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57104
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2b
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