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ATG3 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA118297
Code : LD
Additional Details : Weight : 0.01000kg
Description
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
ATG3 (APG3) is a widely expressed conjugating enzyme for APG8 lipidation, an essential step for the initiation of autophagy. Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Autophagy is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG3 functions as an E2-like enzyme during the initial stages of autophagosome formation by catalyzing the formation of the Atg8-phosphatidylethanolamine (Atg8-PE) conjugate, which is critical for autophagy.Specifications
ATG3 | |
Polyclonal | |
Unconjugated | |
ATG3 | |
2610016C12Rik; APG3; Apg3l; APG3-like; Apg3p; atg3; ATG3 autophagy related 3 homolog; atg3.S; Atg3l; autophagy related 3; autophagy related 3 S homeolog; autophagy-related 3; autophagy-related protein 3; DKFZp564M1178; EGK_11288; FLJ22125; hApg3; MGC15201; PC3-96; Pig1; PIG-1; preconditioning-inducible gene 1 protein; Protein PC3-96; Ubiquitin-like-conjugating enzyme ATG3; XELAEV_18014721mg | |
Rabbit | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot | |
Conc. Not Determined | |
whole serum with no preservative | |
Q6AZ50, Q9CPX6, Q9NT62 | |
ATG3 | |
A synthetic peptide corresponding to a central region of the human ATG3 protein. | |
RUO | |
171415, 64422, 67841 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |