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Invitrogen™ ATG14 Polyclonal Antibody
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Product Code. 17791194
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Quantity:
100 μL
Unit Size:
100µL
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17791194 100 μL 100µL
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Product Code. 17791194 Supplier Invitrogen™ Supplier No. PA5119797

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Description

Rabbit Polyclonal Antibody

Positive Control: Hela cell lysate, MCF-7 cell lysate, HepG2 cell lysate, SiHa cell lysate, rat brain tissue, human colon tissue, mouse testis tissue. Subcellular Location: Endoplasmic reticulum membrane, Cytoplasm, Preautophagosomal structure membrane, autophagosome membrane.

ATG14 (Autophagy related protein homolog 14) is encoded by the ATG14 gene and is located on chromosome 14 in humans. It is also known as ATG14L or BARKOR (Beclin 1-associated autophagy-related key regulator). Autophagy is an evolutionarily conserved process that involves recycling of misfolded cellular proteins and degradation of dysfunctional organelles. Autophagy is induced as a cellular response to nutrient stress which includes the formation of autophagosomes, fusion of these with the lysosome and formation of the autophagolysosome. The Class III PI3-Kinase, Vps34 and its interacting partner Beclin 1 have been shown to form a complex which specifically includes ATG 14 (type 1) or UVRAG (type 2). Atg 14 guides the type 1 complex to the preautophagosomal structure (PAS) and is critical for the initiation of autophagosome formation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATG14
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene Atg14
Gene Accession No. D4A4K3, Q6ZNE5, Q8CDJ3
Gene Alias 4832427M01; Atg14; ATG14 autophagy related 14 homolog; Atg14L; Atg14-like protein; autophagy related 14; autophagy-related protein 14-like protein; Bakor; Barkor; beclin 1-associated autophagy-related key regulator; Beclin 1-Interacting protein; D14Ertd114e; D14Ertd436e; Kiaa0831; RGD1304610; VATG14 autophagy related 14 homolog
Gene Symbols Atg14
Host Species Rabbit
Immunogen Synthetic peptide within human ATG14L aa 421-456.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100504663, 22863, 305831
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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