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  6. Invitrogen™ ATG13 Recombinant Rabbit Monoclonal Antibody (K01_1K67)

Invitrogen™ ATG13 Recombinant Rabbit Monoclonal Antibody (K01_1K67)

Product Code. 30826948
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30826948 100 μL
30828151 50 μL
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Product Code. 30826948 Supplier Invitrogen™ Supplier No. MA563130

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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: QTVRVGTVGT PVGTITLSCA YRINLAFMST RQFERTPPIM GIIIDHFVDR PYPSSSPMHP CNYRTAGEDT GVIYPSVEDS QEVCTTSFST SPPSQLSSSR LSYQPAALGV GSADLAYPVV FAAGLNATHP HQLMVPGKEG GVPLAPNQPV HGTQADQERL ATCTPSDRTH CAATPSSSED TETVSNSSEG RASPHDVLET IFVRKVGAFV NKPINQVTLT SLDIPFAMFA PKNLELEDTD PMVNPPDSPE Highest antigen sequence identity to the following orthologs: Mouse - 90%, Pig - 96%, Cynomolgus monkey - 98%.

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG13 forms a complex with ULK1 and ULK2, the mammalian homologs of ATG1, and with FIP200. This complex is a target of TOR phosphorylation under normal conditions; inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy. Knockdown of ATG13 inhibits autophagosome formation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATG13
Applications Western Blot
Classification Recombinant Monoclonal
Clone K01_1K67
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 40% glycerol, 150mM NaCl, 0.05% BSA and 0.01% sodium azide; pH 7.4
Gene ATG13
Gene Accession No. O75143, Q91YI1
Gene Alias 1110053A20Rik; Atg13; ATG13 autophagy related 13 homolog; autophagy related 13; autophagy-related protein 13; D2Ertd391e; FLJ20698; Harbi1; Harbi1l; harbinger transposase derived 1; KIAA0652; OTTHUMP00000233321; OTTHUMP00000233322; OTTHUMP00000233323; OTTHUMP00000233324; OTTHUMP00000233325; OTTHUMP00000233326; PARATARG8; RGD1310685
Gene Symbols ATG13
Host Species Rabbit
Immunogen Recombinant protein of human KIAA0652 (aa 169-418).
Purification Method Protein A/G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 362164, 51897, 9776
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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