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  5. Tocris Bioscience™ ASP 3026

Tocris Bioscience™ ASP 3026
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Product Code. 18701698
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18730518 50 mg 50mg
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Product Code. 18701698 Supplier Tocris Bioscience™ Supplier No. 5310/10

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Description

Potent anaplastic lymphoma kinase (ALK) inhibitor; also potent ACK inhibitor

ASP 3026 is a potent anaplastic lymphoma kinase (ALK) inhibitor (IC50 = 3.5 nM). Also inhibits Ack and ROS1 activity (IC50 values are 5.8 and 8.9 nM respectively). Attenuates proliferation, and induces apoptosis of NPM-ALK+ T cell anaplastic large-cell lymphoma (ALCL) cells in vitro. Suppresses tumor growth of NPM-ALK+ ALCL cell xenografts in mice. Causes tumor shrinkage in hEML4-ALK transgenic mice. Orally available.
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Specifications

Chemical Name or Material N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine
CAS 1097917-15-1
Quantity 10 mg
Target ALK Inhibitors
Molecular Formula C29H40N8O3S
Formula Weight 580.74
Purity >99%
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