ASAH1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16808243	Proteintech 11274-1-AP-20UL	20 μL
16898233	Proteintech 11274-1-AP-150UL	150 μL

Description

Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH1 is an acid ceramidase and key regulator of ceramide metabolism. Mutations in this gene results in Farber Lipogranulomatosis, a fatal human genetic disorder that results in the painful swelling of the joints and tendons and pulmonary insufficiency, while a complete knockout of its expression is lethal in mice. Recent studies have shown elevated levels of ASAH1 in Alzheimer′s disease (AD) patients correlating with a reduction in sphingomyelin and elevation of ceramide. Pretreatment of cultured neurons with recombit AHAH1 prevented the cells from undergoing A-beta (Ab)-induced apoptosis. Multiple isoforms of this protein are known to exist.

Specifications

• Antigen: ASAH1
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Immunocytochemistry, Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Mouse, Rat, Human
• Gene Accession No.: Q13510, Q6P7S1, Q9WV54
• Gene ID (Entrez): 11886, 427, 84431
• Immunogen: ASAH1 Fusion Protein Ag1799
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: ASAH1

• Concentration: 0.15 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: AC, Acid ceramidase, Acylsphingosine deacylase, ASAH, ASAH1, HSD 33, PHP, PHP32, Putative 32 kDa heart protein
• Gene Symbols: Asah1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody