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AS601245, MedChemExpress

Product Code. 16497067
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Quantity:
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10 mg
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50mg
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Product Code. 16497067

Brand: Medchem Express HY11010

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Description

MedChemExpress AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties.

AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties.

Specifications

Chemical Name or Material AS601245
Physical Form Solid
CAS 345987-15-7
Color Yellow
Quantity 5 mg
Purity Grade Notes Research
Molecular Formula C20H16N6S
For Use With (Application) Cancer-Kinase/protease
Solubility Information DMSO : 10 mg/mL (26.85 mM; Need ultrasonic)
SMILES N#CC(C1=CC=NC(NCCC2=CC=CN=C2)=N1)C3=NC4=CC=CC=C4S3
Molecular Weight (g/mol) 372.45
Formula Weight 372.45
Percent Purity 98.7%
Grade Research
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Research purposes only

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