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Eurofins DiscoverX ARK5 Protein, Active
Description
ARK5 (AMPK related kinase 5) is a serine/threonine kinase and a member of the AMPK family of protein kinases. In response to stimulation by Akt, ARK5 prevents cell death induced by glucose starvation and death receptor activation in tumor cells as a result of inhibition of caspase 8 activation via preservation of c-FLIP. ARK5 can also negatively regulate procaspase-6 via direct phosphorylation at Ser257, leading to resistance to the FasL/Fas signaling system.
GenBank NM_014840
Specifications
Specifications
| Formulation | mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. |
| Molecular Weight (g/mol) | 78 kDa |
| Quantity | 10 μg |
| Species | Human |
| Recombinant | Recombinant |
| Protein Tag | N-terminal 6His |
| Expression System | Recombinant enzyme expressed in Sf21 insect cells |
| Protein Form | Truncated |
| Purity or Quality Grade | ≥66% |
| Protein | ARK5, active |
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