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Invitrogen™ ARHGEF17 Polyclonal Antibody

Product Code. 12808622
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Quantity:
100 μg
Unit Size:
100µg
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12808622 100 μg 100µg
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Product Code. 12808622 Supplier Invitrogen™ Supplier No. PA520440

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Description

Rabbit Polyclonal Antibody

A suggested positive control is Jurkat cell lysate. PA5-20440 can be used with blocking peptide PEP-0557.

Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 is a Rho-specific GEF with novel structural and regulatory properties and predominant expression in the heart. It couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful targets therapeutically.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ARHGEF17
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene ARHGEF17
Gene Accession No. Q96PE2
Gene Alias 164 kDa Rho-specific guanine-nucleotide exchange factor; 8030463K16; AI428794; Arhgef17; AW558066; BC035332; Kiaa0337; mKIAA0337; P164RHOGEF; p164-RhoGEF; Rho guanine nucleotide exchange factor (GEF) 17; Rho guanine nucleotide exchange factor 17; Rho-specific guanine-nucleotide exchange factor 164 kDa; TEM4; Tumor endothelial marker 4
Gene Symbols ARHGEF17
Host Species Rabbit
Immunogen An 18 amino acid peptide near the center of human TEM4.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9828
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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