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STEMCELL Technologies ArciTect™ Cas9 Nuclease

Product Code. 17119301
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Quantity:
100 μg
300 μg
Unit Size:
100µg
300µg
This item is not returnable. View return policy

Product Code. 17119301

Brand: STEMCELL Technologies 76002

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This item is not returnable. View return policy

Description

Cas9 nuclease (4 μg/μL) for the generation of double-strand breaks in CRISPR-Cas9 genome editing

  • ArciTect™ Cas9 Nuclease requires association with a guide RNA—e.g. ArciTect™ sgRNA (Catalog #200-0013) or a duplex composed of ArciTect™ tracrRNA (Catalog #76016) and ArciTect™ crRNA (Catalog #76010)—to form a ribonucleoprotein (RNP) complex
  • This RNP complex then creates double-strand breaks at site-specific locations in the genome
  • ArciTect™ Cas9 Nuclease contains a nuclear localization signal at the N-terminus, ensuring that the RNP complex translocates to the nucleus, thereby increasing the efficiency of genome editing
  • As the RNP complex is fully functional upon transfection, it allows for immediate activity following translocation to the nucleus
  • The RNP complex is degraded over 48 hours, allowing sufficient time for genome editing to occur while reducing off-target effects that can be caused by the continuous presence of the RNP complex
  • The ArciTect™ Cas9 nuclease has been validated for use with human PSCs, T cells, hematopoietic stem & progenitor cells, and intestinal organoids

Specifications

Quantity 100 μg
Cell Type Pluripotent Stem Cells
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