Invitrogen™ AQR Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5109403

Product Code. 17177333

Description

Immunogen sequence: KEFLLELLVS RHERRISQIQ QLNQMPLYPT EKIIWDENIV PTEYYSGEGC LALPKLNLQF LTLHDYLLRN FNLFRLESTY EIRQDIEDSV SRMKPWQSEY GGVVFGGWAR MAQPIVAFTV VEVAKPNIGE NWPTRVRADV TINLNVRDHI KDEWEGLRKH DVCFLITVRP TKPYGTKFDR RRPFIEQVGL VYVRGCEIQG MLDDKGRVIE DGPEPRPNLR GESRTFRVFL DPNQYQQDMT NTIQNGAEDV YETFNIIMRR KPKENNFKAV LETIRNLMNT DCVVPDWLHD IILGYGDPSS A.

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:25599396, PubMed:28502770, PubMed:28076346). Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis (PubMed:16949364). Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly (PubMed:16949364). May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing (PubMed:16949364). Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) (PubMed:25599396). [UniProt].

Specifications

• Antigen: AQR
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AQR
• Gene Alias: Aqr; aquarius; aquarius homolog; aquarius intron-binding spliceosomal factor; AW495846; fSAP164; functional spliceosome-associated protein 164; IBP160; intron-binding protein aquarius; intron-binding protein of 160 kDa; Kiaa0560; mKIAA0560; RNA helicase aquarius
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11834, 366163, 9716
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.95 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: O60306, Q8CFQ3
• Gene Symbols: AQR
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 400-700 of human AQR (NP_055506.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG