APP (Amyloid Precursor Protein) Mouse, Biotin, Clone: 22C11, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-9749-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15587366

Quantity Price
1 £ 67.82 / 25µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Host Species Mouse
Quantity 25μg
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate Biotin
Antigen APP (Amyloid Precursor Protein)
Isotype IgG1
Applications Immunocytochemistry
Applications Microscopy
Storage Requirements Store at 2-8°C. Do not freeze.
Species Reactivity Human, Mouse, Rat
Gene Alias Alzheimer Precursor Protein A4
Monoclonal or Polyclonal Monoclonal
Clone 22C11
Concentration 0.5mg/mL
Format Conjugated
Regulatory Status RUO
Primary or Secondary Primary

The monoclonal antibody 22C11 recognizes human, mouse, and rat APP (Amyloid Precursor Protein). APP is expressed in high abundance in the central nervous system and has three major isoforms resulting from alternative splicing. APP plays a role in synaptic formation and repair, anterograde neuronal transport, iron export, and hormonal regulation. Secreted APP (sAPP) may have neuroprotective effects against neurotoxic insult, oxidative stress, and excitotoxicity. APP belongs to a family that contains at least two homologs, amyloid precursor-like proteins 1 and 2 (APLP1 and APLP2). Similarities between APP and APLP, especially APLP2, suggest that APLP could share and compensate for the function of APP. Proteolytic cleavage of APP results in the generation of beta amyloid, which is the primary component of senile plaques. Senile plaques are one of the major histopathologic features of Alzheimer’s disease. Abnormal regulation and processing of APP also plays a role in Down’s syndrome, early onset familial Alzheimer’s disease, cerebral hemorrhage, and arthritis.

This 22C11 antibody reacts with pre-A4 and recognizes all three isoforms of APP (immature, sAPP, and mature). This 22C11 antibody is known to cross react with APLP2.