Invitrogen™ APOE Recombinant Rabbit Monoclonal Antibody (16H22L18)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ 701241

Product Code. 15387084

Description

This antibody is predicted to react with non-human primate and mouse based on sequence homology. Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Apo E (Apolipoprotein E) plays an important role in the metabolism of lipids in the plasma, and is also is a constituent of various plasma lipoprotein-lipid particles. The protein is synthesized in liver, brain, spleen, and the kidney, and concentrations are high in interstitial fluids, where it plays a role in distributing cholesterol from cells where cholesterol is in excess to cells which require cholesterol. Apo E also plays an important role in the formation of very low density lipoprotein and chylomicrons. The Apo E gene is located on chromosome 19 at position 19q13. 2.

Specifications

• Antigen: APOE
• Classification: Recombinant Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: P02649, P02650, P08226
• Gene Symbols: APOE
• Immunogen: Peptide corresponding to amino acids 240-251 of human ApoE.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot, Immunocytochemistry
• Clone: 16H22L18
• Conjugate: Unconjugated
• Gene: APOE
• Gene Alias: AD2; AI255918; APOE; apo-E; ApoE4; APOEA; Apolipoprotein; apolipoprotein E; apolipoprotein E3; apolipoprotein E4; Apoprotein; B2G1; BG; LDLCQ5; LPG; MGC1571
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 11816, 25728, 348
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid
• Green Features: Responsibly packaged