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Invitrogen™ APOBEC3C Polyclonal Antibody
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Product Code. 17157333
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Quantity:
100 μL
Unit Size:
100µL
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17157333 100 μL 100µL
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Product Code. 17157333 Supplier Invitrogen™ Supplier No. PA5109401

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MNPQIRNPMK AMYPGTFYFQ FKNLWEANDR NETWLCFTVE GIKRRSVVSW KTGVFRNQVD SETHCHAERC FLSWFCDDIL SPNTKYQVTW YTSWSPCPDC AGEVAEFLAR HSNVNLTIFT ARLYYFQYPC YQEGLRSLSQ EGVAVEIMDY EDFKYCWENF VYNDNEPFKP WKGLKTNFRL LKRRLRESLQ.

APOBEC (apolipoprotein B mRNA editing enzyme, catalytic) proteins inhibit retroviruses by deaminating cytosine residues of viral RNA and DNA. The seven APOBEC3 genes or pseudogenes are found in a cluster thought to result from gene duplication on chromosome 22. Like APOBEC3G, APOBEC3F deaminates deoxycytosine to deoxyuracil in the minus strand of HIV-1 DNA, resulting in G to A hypermutation in the plus strand of DNA. Thus, APOBEC3G and APOBEC3F provide a mechanism for innate immunity to retroviruses, and are also likely contribute to sequence variation observed in many viruses. Viral infectivity factor (Vif) imparts APOBEC3G and APOBEC3F resistance to HIV through impaired translation of their mRNA and accelerated posttranslational degradation of the APOBEC3 proteins by the 26S proteasome. Interestingly, HIV-1 Vif cannot form a complex with APOBEC3G or APOBEC3F of mouse origin as it does with the human protein, and thus mouse APOBEC3G and APOBEC3F function as a potent inhibitors of wildtype HIV-1 replication, where human APOBEC3G and APOBEC3F are only able to inhibit Vif-deficient HIV-1 replication. This implies that induction of APOBEC3G and APOBEC3F activity or a method of blocking their interaction with Vif may provide a method for therapeutic intervention.
TRUSTED_SUSTAINABILITY

Specifications

Antigen APOBEC3C
Applications ELISA, Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 2.45 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene APOBEC3C
Gene Accession No. Q9NRW3
Gene Alias A3C; APOBEC1L; APOBEC1-like; APOBEC3C; apolipoprotein B editing enzyme catalytic polypeptide-like 3C; apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3C; apolipoprotein B mRNA editing enzyme catalytic subunit 3C; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C; ARDC2; ARDC4; ARP5; bK150C2.3; DNA dC->dU-editing enzyme APOBEC-3C; MGC19485; PBI; Phorbolin I; probable DNA dC->dU-editing enzyme APOBEC-3C
Gene Symbols APOBEC3C
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human APOBEC3C (NP_055323.2).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27350
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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