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Tocris Bioscience™ API-2
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Product Code. 18075472
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10mg
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Product Code. 18075472

Brand: Tocris Bioscience™ 2151/10

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Description

Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral

API-2 is a selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3β and AFX. Induces apoptosis and growth arrest in vitro, preferentially in human cancer cells with elevated levels of Akt. Potently and selectively inhibits growth of Akt-overexpressing tumors in mice. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.
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Specifications

CAS 35943-35-2
Quantity 10 mg
Molecular Formula 1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
Product Type API-2
Purity 99%
Molecular Weight (g/mol) M.W. (Observed): 320.31
Inhibitors API-2

For Research Use Only

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