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API-1, Tocris Bioscience™
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Product Code. 18015342
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10 mg
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Product Code. 18015342 Supplier Tocris Bioscience Supplier No. 3897/10

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Description

Selective Akt/PKB inhibitor. Antitumor

Akt/protein kinase B (PKB) inhibitor. Binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation. Inhibits EGF-induced kinase activity of Akt1, Akt2 and Akt3. Induces cell growth arrest and apoptosis in human cancer cells expressing constitutively active Akt. Displays antitumor activity in vitro and in vivo.
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Specifications

CAS 36707-00-3
Molecular Formula C13H15N5O6
Quantity 10 mg
Synonym api-1, 4-amino-8-3,4-dihydroxy-5-hydroxymethyl oxolan-2-yl-5-oxo, 4-amino-5,8-dihydro-5-oxo-8-?-d-ribofuranosyl-pyrido 2,3-d pyrimidine-6-carboxamide, 4-amino-5,8-dihydro-5-oxo-8-beta-d-ribofuranosyl-pyrido 2,3-d pyrimidine-6-carboxamide, 4-amino-8-2r,3r,4s,5r-3,4-dihydroxy-5-hydroxymethyl oxolan-2-yl-5-oxopyrido 2,3-d pyrimidine-6-carboxamide
InChI Key SPBWHPXCWJLQRU-FITJORAGSA-N
SMILES C1=C(C(=O)C2=C(N1C3C(C(C(O3)CO)O)O)N=CN=C2N)C(=O)N
IUPAC Name 4-amino-8-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide
Molecular Weight (g/mol) 337.292
PubChem CID 24773090
Formula Weight 337.29
Percent Purity >96%
Chemical Name or Material API-1
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