Invitrogen™ APH1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA523466

Product Code. 13297838

Description

The amino acid sequence used as immunogen is 88% homologous in Chicken.

APH1 is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). The gamma-secretase complex is minimally composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2, although other components may exist. APH1 probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.

Specifications

• Antigen: APH1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: APH1A
• Gene Alias: 6530402N02Rik; anterior pharynx defective 1 homolog A; anterior pharynx defective 1a homolog; anterior pharynx defective 1a homolog (C. elegans); APH1; APH-1; aph-1 homolog A, gamma secretase subunit; aph-1 homolog A, gamma-secretase subunit; Aph1a; APH-1a; APH1A gamma secretase subunit; Aph-1alpha; CGI-78; Gamma-secretase subunit APH-1A; hypothetical protein LOC539247; presenilin-stabilization factor; PSF; RGD1311546; RP4-790G17.3; UNQ579/PRO1141
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 100054581, 100855839, 51107, 539247
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.05% BSA and 0.05% sodium azide
• Gene Accession No.: Q96BI3
• Gene Symbols: APH1A
• Immunogen: A portion of amino acids 80-145 of human APH1A.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Canine, Monkey, Bovine, Horse, Marsupial
• Product Type: Antibody
• Isotype: IgG