Invitrogen™ APEX2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA129809

Product Code. 11586812

Description

PA1-29809 detects APEX2 from human samples.

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER).

Specifications

• Antigen: APEX2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: APEX2
• Gene Alias: AP endonuclease 2; AP endonuclease XTH2; Ape2; APEX nuclease (apurinic/apyrimidinic endonuclease) 2; APEX nuclease 2; APEX nuclease-like 2; APEX2; APEXL2; apurinic/apyrimidinic endodeoxyribonuclease 2; apurinic/apyrimidinic endonuclease 2; apurinic/apyrimidinic endonuclease-like 2; Apurinic-apyrimidinic endonuclease 2; C430040P13Rik; DNA-(apurinic or apyrimidinic site) lyase 2; RP5-884M20.3; XTH2; ZGRF2; zinc finger, GRF-type containing 2
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 27301
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.05% BSA and 0.02% sodium azide
• Gene Accession No.: Q9UBZ4
• Gene Symbols: APEX2
• Immunogen: EELRALDSEGRALLTQHKI (aa122-140) and GQAKTSEAKDEKELRTSF (aa438-455) peptides of human APEX2.
• Quantity: 200 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG