Invitrogen™ APC7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA542034

Product Code. 15575202

Description

Peptide sequence: ALSLDPNDQK SLEGMQKMEK EESPTDATQE EDVDDMEGSG EEGDLEGSDS Sequence homology: Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%.

Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC7 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. APC7 is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with various transcription coactivators.

Specifications

• Antigen: APC7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ANAPC7
• Gene Alias: Anapc7; anaphase promoting complex subunit 7; anaphase-promoting complex subunit 7; APC7; AW545589; Cyclosome subunit 7; prediabetic NOD sera-reactive autoantigen; si:ch211-127h20.1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51434
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q9UJX3
• Gene Symbols: ANAPC7
• Immunogen: Synthetic peptide directed towards the C-terminal of human ANAPC7.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG