Invitrogen™ APC11 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA554543

Product Code. 15782471

Description

Immunogen sequence: SPWCLDHSCD LFGITDQVSA DGPRACRQGA RRRLPAGVGP VLPLLPHALH PQVAARTAGA AALPHVPPGM EVQGV Highest antigen sequence identity to the following orthologs: Mouse - 30%, Rat - 29%.

Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. [UniProt].

Specifications

• Antigen: APC11
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ANAPC11
• Gene Alias: 1110011I19Rik; Anapc11; anaphase promoting complex subunit 11; anaphase promoting complex subunit 11 (yeast APC11 homolog); anaphase promoting complex subunit 11 homolog; anaphase-promoting complex subunit 11; APC11; APC11 anaphase promoting complex subunit 11 homolog; Apc11p; Cyclosome subunit 11; hepatocellular carcinoma-associated RING finger protein; HSPC214; R75218; RGD1561880
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51529
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9NYG5
• Gene Symbols: ANAPC11
• Immunogen: Recombinant protein corresponding to Human APC11. Recombinant protein control fragment (Product #RP-93303).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG