APC1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 21748-1-AP-20UL

Product Code. 16851345

Description

Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC1, also known as mitotic checkpoint regulator (MCPR), is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex.

Specifications

• Antigen: APC1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ANAPC1
• Gene Alias: ANAPC1, APC1, Mitotic checkpoint regulator, TSG24
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 17222, 311412, 64682
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.39 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P53995, Q9H1A4
• Gene Symbols: Anapc1
• Immunogen: APC1 Fusion Protein Ag13399
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Rat, Human, Mouse
• Product Type: Antibody
• Isotype: IgG