Invitrogen™ APBA2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5139840

Product Code. 17814360

Description

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: EEGITYYIRY CPEDDSYLEG MDCNGEEYLA HSAHPVDTDE CQEAVEEWTD SAGPHPHGHE AEGSQDYPDG QLPIPEDEPS VL Highest antigen sequence indentity to the following orthologs: Mouse - 84%, Rat - 84%.

APBA2, a member of the X11 protein family, is a phosphotyrosine-binding domain protein and is a neuronal adapter protein that interacts with amyloid precursor protein (APP) and neuritic plaques in the brains of patients with Alzheimer's disease. It stabilizes APP and inhibits production of proteolytic APP fragments including the Abeta peptide that is deposited in the brains of Alzheimer's disease patients. APBA2 is believed to be involved in signal transduction processes and is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Recent reports suggest that it may also be a candidate gene for autism.

Specifications

• Antigen: APBA2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: APBA2
• Gene Alias: Adapter protein X11beta; amyloid beta (A4) precursor protein-binding family A member 2 (X11-like); amyloid beta (A4) precursor protein-binding, family A, member 2; amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like); amyloid beta A4 precursor protein-binding family A member 2; amyloid beta precursor protein binding family A member 2; Amyloid-beta A4 precursor protein-binding family A member 2; Apba2; D15S1518E; HsT16821; LIN-10; MGC:14091; Mint 2; Mint2; mint-2; mXllL; Neuronal Munc18-1-interacting protein 2; neuron-specific X11L protein; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; X11-BETA; X11L; X11-like; X11-like protein; XllL
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 321
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q99767
• Gene Symbols: APBA2
• Immunogen: Recombinant protein corresponding to Human APBA2. Recombinant protein control fragment (Product #RP-105962).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG