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Invitrogen™ APAF1 Polyclonal Antibody

Product Code. 12828112
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Quantity:
100 μg
Unit Size:
100µg
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12828112 100 μg 100µg
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Product Code. 12828112 Supplier Invitrogen™ Supplier No. PA519894

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Description

Rabbit Polyclonal Antibody

In Western blot applications, this antibody detects a band at ~130kDa. A suggested positive control is human heart tissue lysate.

APAF1 gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen APAF1
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene APAF1
Gene Accession No. O14727, O88879, Q9EPV5
Gene Alias 6230400I06Rik; APAF1; APAF-1; Apaf1l; apoptotic peptidase activating factor 1; apoptotic protease activating factor 1; apoptotic protease-activating factor 1; CED4; DKFZp781B1145; fog; forebrain overgrowth; KIAA0413; mKIAA0413
Gene Symbols APAF1
Host Species Rabbit
Immunogen A peptide corresponding to amino acids near the carboxy terminus of human Apaf1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11783, 317, 78963
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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